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Sku: P104583-50 μl
Categories: Primary Antibodies

Specification

Full name CAPN6 rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
Swissprot No Q9Y6Q1
Gene Accession BC000730
WB Predicted band size
WB Positive control P104583-WB-1-P
WB Recommended dilution 75 kDa
IHC predicted cell location Predicted cell location: Cytoplasm
IHC positive control Positive control: Human liver cancer
IHC Recommed dilution Recommended dilution: 50-100

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P104583-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue or CAPN6 antigen-treated (Neutralization experiment) using P104583(CAPN6 Antibody) at dilution 1/70

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