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Specification
| Full name | BCAS4 rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | The gene encoding BCAS4 (Breast carcinoma-amplified sequence 4), a 211 amino acid protein, is found in a region on chromosome 20 that is frequently amplified in human breast cancer. This 20q13 locus amplification is found in 12%–39% of primary breast tumors, which correlates with a 17q23 locus amplification that is found in 20% of primary breast tumors. The amplification and translocation between the BCAS4 gene and the BCAS3 gene, with a 17q23 locus, results in a fusion transcript that is overexpressed in MCF-7 cells. Also, deletion of chromosomal region 20q13.13-q13.2 and resultant deletion of BCAS4, as well as three other genes, is the cause of Okihiro syndrome, a disease characterized by ocular and upper limb anomalies. BCAS4 is normally expressed in thymus, kidney, spleen, placenta and brain. There are three isoforms of BCAS4 which are produced as a result of alternative splicing events. |
| Swissprot No | Q8TDM0 |
| Gene Accession | NP_060313 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue or BCAS4 antigen-treated (Neutralization experiment) using P102641(BCAS4 Antibody) at dilution 1/50 |
| WB Positive control | P102641-WB-1-P |
| WB Recommended dilution | 23 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm |
| IHC positive control | Positive control: Human gastic cancer |
| IHC Recommed dilution | Recommended dilution: 50-200 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P102641-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human gastic cancer tissue or BCAS4 antigen-treated (Neutralization experiment) using P102641(BCAS4 Antibody) at dilution 1/50
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