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Full name | BAP1 rabbit polyclonal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | rabbit polyclonal |
Applications | WB, IHC |
Host | Rabbit |
Clone type | rabbit polyclonal |
Target Background | This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. |
Swissprot No | Q92560 |
Gene Accession | BC001596 |
WB Predicted band size | |
WB Positive control | P112843-WB-1-P |
WB Recommended dilution | 80 kDa |
IHC predicted cell location | Predicted cell location: Nucleus and Cytoplasm |
IHC positive control | Positive control: Human colorectal cancer |
IHC Recommed dilution | Recommended dilution: 50-200 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
P112843-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human colorectal cancer tissue using P112843(BAP1 Antibody) at dilution 1/70
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