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Sku: P106021-50 μl
Categories: Primary Antibodies

Specification

Full name APP rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Swissprot No P05067
Gene Accession NP_000475.1
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or APP antigen-treated (Neutralization experiment) using P106021(APP Antibody) at dilution 1/35
WB Positive control P106021-WB-1-P
WB Recommended dilution 87 kDa
IHC predicted cell location Predicted cell location: Nucleus
IHC positive control Positive control: Human prostate cancer
IHC Recommed dilution Recommended dilution: 50-100

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P106021-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue or APP antigen-treated (Neutralization experiment) using P106021(APP Antibody) at dilution 1/35

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