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Product Information
| Expression Host | HEK293 cells |
| QC Testing Purity | > 90 % as determined by SDS-PAGE |
| Purification | Protein A purified from cell culture supernatan |
| Endotoxin Level | < 0.1 EU per μg of the protein as determined by the LAL method |
| Formulation | Supplied as a 0.22μm filtered solution in PBS, PH 7.4. |
| Stability & Storage | 24 months at 2℃ to 8℃. Avoid repeated freeze-thaw cycles. |
Background
CD52 is a widely distributed antigen belonging to a GPI anchored glycoprotein with only twelve amino acid residues (GQNDTSQTSSPS). CD52 can be found on the surface of lymphocytes, monocytes,eosophils and dendritic cells in hematopoietic system. With a density of up to 5×105 molecules on lymphocytes, CD52 antigens express on many lymphoid cell malignancies and certain acute myeloid leukemia cells. When CD52 molecules are crosslinked with mAb, it triggers a series of signaling within the target cells. The signaling caused by the activation of CD52 molecules is similar to what caused by anti-CD3 antibodies. When CD52 molecules are triggered, PMA (Phorbol Myristate acetate, acetylmyridrobol ester) can promote the proliferation and secretion of cytokines in normal human CD4 + and CD8 + T lymphocytes in vitro.
References
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Quigley MM, Bethel KJ, Sharpe RW.CD52 expression in hairy cell leukemia[ J]. Am J Hematol, 2003 , 74(4):227-230.
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Rowan W, Tite J, Topley P .Cross-linking of the CAMPATH-1 antigen (CD52)mediates growth inhibition in human B- and T- lymphoma cell lines, and subsequent emergence of CD52-deficient cells[ J][J]. Immunology, 1998,95:427-436.
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