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|Expression Host||HEK293 cells|
|QC Testing Purity||> 90 % as determined by SDS-PAGE|
|Purification||Protein A purified from cell culture supernatan|
|Endotoxin Level||< 0.1 EU per μg of the protein as determined by the LAL method|
|Formulation||Supplied as a 0.22μm filtered solution in PBS, PH 7.4.|
|Stability & Storage||24 months at 2℃ to 8℃.
Avoid repeated freeze-thaw cycles.
CD52 is a widely distributed antigen belonging to a GPI anchored glycoprotein with only twelve amino acid residues (GQNDTSQTSSPS). CD52 can be found on the surface of lymphocytes, monocytes,eosophils and dendritic cells in hematopoietic system. With a density of up to 5×105 molecules on lymphocytes, CD52 antigens express on many lymphoid cell malignancies and certain acute myeloid leukemia cells. When CD52 molecules are crosslinked with mAb, it triggers a series of signaling within the target cells. The signaling caused by the activation of CD52 molecules is similar to what caused by anti-CD3 antibodies. When CD52 molecules are triggered, PMA (Phorbol Myristate acetate, acetylmyridrobol ester) can promote the proliferation and secretion of cytokines in normal human CD4 + and CD8 + T lymphocytes in vitro.
Quigley MM, Bethel KJ, Sharpe RW.CD52 expression in hairy cell leukemia[ J]. Am J Hematol, 2003 , 74(4):227-230.
Rowan W, Tite J, Topley P .Cross-linking of the CAMPATH-1 antigen (CD52)mediates growth inhibition in human B- and T- lymphoma cell lines, and subsequent emergence of CD52-deficient cells[ J][J]. Immunology, 1998,95:427-436.
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