0 item(s)
View cart
You have no items in your shopping cart.
IFNA; IFNA2; IFNA2b; IFNalpha; IFN-alpha; IFN-alphaA; INFA2; interferon alpha 2; LeIF D
$198.00
Sku: RP456-10UG
Bcakground
Interon-alpha (IFN-alpha),also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction (1, 2). IFN-alpha has both anti-viral and immunomodulatory activities on target cells. Type I Interferons (IFNs) are well-known cytokines that exert antiviral activity, antitumor activity, and immunomodulatory effects. Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. Among the IFN-α genes, a total of 28 different sequence variants have been described. The three principal subtypes of IFNα-2 are designated α-2a, α-2b, and α-2c. IFNα-2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant (2, 3).
Reference
1. Wang. et al. (2004) J Neuroimmunol. 156(1-2): 107-12.
2. Groopman JE, et al. (1984) Ann Intern Med. 100(5): 671-6.
3. Krueger JM, et al. (1987) Int J Immunopharmacol. 9(1): 23-30.
Specifications
| Synonyms | Human IFNA2; IFNA2a; IFNalpha 2; IFN-alpha 2; IFN-alphaA; INFA2; interferon alpha A |
| Accession # | V00549 |
| Source | Human embryonic kidney cell, HEK293-derived human IFN-alpha A protein |
| Cys24-Glu188 | |
| Predicted Moleucular weight | 19.2 kDa |
Components and Storage
| Formulation | Solution protein |
| Dissolved in sterile PBS buffer | |
| This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening. | |
| Storage and Stability | Avoid repeated freeze-thaw cycles. |
| It is recommended that the protein be aliquoted for optimal storage. | |
| 12 months from date of receipt, -20 to -70 °C as supplied. | |
| Shipping | Shipping with dry ice. |
Quality
| Purity | > 95%, determined by SDS-PAGE. |
| Endotoxin Level | <0.010 EU per 1 ug of the protein by the LAL method. |
| Activity | Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV) |
| The EC50 for interferon in this assay is 0.5-3 pg/mL |
SDS-PAGE
Gel filtration
Bioactivity
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
No data
