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$230.00
Sku: TL-772-0050
Availability:
QUICK SHIP
In stock & estimated to ship in 1-2 days by June 06, 2026
Description
Oncostatin M (OSM) belongs to the interleukin-6 cytokine family.
OSM is a glycoprotein secreted by activated monocytes, macrophages, T lymphocytes, and dendritic cells.
OSM was first discovered as a factor that inhibits melanoma cell growth.
OSM inhibits liver cancer cell proliferation by activating STAT3 signaling and upregulating oncogene c-Myc expression, while also accelerating cell senescence.
In addition, OSM participates in liver cell proliferation and tissue remodeling during liver regeneration.
OSM can also inhibit the adipogenic differentiation of human bone marrow mesenchymal stem cells and stimulate their osteogenic differentiation.
Specifications
| Parameter | Specification |
|---|---|
| Expression Host | HEK293 cells |
| Synonyms | Oncostatin M; OSM; MGC20461 |
| Protein Sequence | Amino acid sequence: Ala26–Arg221 of human OSM (UniProt ID: P13725) |
| Molecular Weight | Predicted molecular weight is 23.24 kDa |
| Purity | >95%, analyzed by SDS-PAGE and HPLC |
| Endotoxin | <1 EU/μg |
| Purification Method | Chromatographic purification |
| Appearance | White lyophilized powder |
| Activity | Refer to COA for details |
Features
- ✔ Recombinant Human Oncostatin M Protein
Human OSM corresponding to Ala26–Arg221 produced in HEK293 cells with a predicted molecular weight of 23.24 kDa. - ✔ High-Purity Chromatographic Preparation
Purity >95% confirmed by SDS-PAGE and HPLC following chromatographic purification. - ✔ Controlled Endotoxin Level
Endotoxin content <1 EU/μg, supporting reliable performance in sensitive in vitro cell culture experiments. - ✔ Defined Lyophilized Protein Format
Supplied as a white lyophilized powder with verified protein identity and consistent biological activity.
Applications
Liver Regeneration & Hepatocyte Biology
Participates in hepatocyte proliferation and tissue remodeling processes during liver regeneration studies.
Cancer Biology Research
Used to investigate STAT3 signaling activation and c-Myc regulation involved in liver cancer cell proliferation and senescence mechanisms.
Mesenchymal Stem Cell Differentiation
Inhibits adipogenic differentiation of human bone marrow mesenchymal stem cells while promoting osteogenic differentiation.
Stem Cell Culture Systems
Applicable for stem cell culture models including MSC and iPSC research environments.
Storage
Store below -20°C
Instructions
Centrifuge before reopening the tube. Dissolve the lyophilized protein in distilled water. It is recommended to reconstitute the concentration to greater than 100 μg /mL.
After reconstitution, the protein can be stored at -80℃ for 3-6 months and at 2-8℃ for 2-7 days. For optimal storage, aliquot the protein and minimize freeze-thaw cycles.
Precautions
This product is only suitable for in vitro cell culture and cannot be used directly in clinical treatment.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
