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Description
CD52 is a widely distributed antigen belonging to a GPI anchored glycoprotein with only twelve amino acid residues (GQNDTSQTSSPS). CD52 can be found on the surface of lymphocytes, monocytes, eosophils and dendritic cells in hematopoietic system. with a density of up to 5×10⁵molecules on lymphocytes, CD52 antigens express on many lymphoid cell malignancies and certain acute myeloid leukemia cells. When CD52 molecules are crosslinked with mAb, it triggers a series of signaling within the target cells. The signaling caused by the activation of CD52 molecules is similar to that caused by anti-CD3 antibodies. When CD52 molecules are triggered, PMA (Phorbol Myristate acetate, acetylmyridrobol ester) can promote the proliferation and secretion of cytokines in normal human CD4⁺and CD8⁺Tlymphocytes in vitro.
Characterization
| Cytokines | |
| Expression Host | HEK293 cells |
| QC Testing Purity | > 90 % as determined by SDS-PAGE. |
| Endotoxin | < 0.1EU per μg of the protein as determined by the LAL method. |
| Activity | The binding rate with MC/CAR |
| Formulation | Supplied as a 0.22μm filtered solution in PBS, PH 7.4. |
| Stability | 24 months at 2℃ to 8℃. Avoid repeated freeze-thaw cycles. |
| Storage | 24 months at 2℃ to 8℃. Avoid repeated freeze-thaw cycles. |
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