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RUO Grade- Active- His-tag
$220.00
Sku: TL-636-0050
Availability:
QUICK SHIP
In stock & estimated to ship in 1-2 days by March 13, 2026
Description
Recombinant human erythropoietin (EPO) is a glycosylated cytokine essential for erythropoiesis, specifically promoting the proliferation and differentiation of erythroid progenitor cells (CFU-E) into mature erythrocytes.
While renal production maintains physiological EPO levels in adults, hepatic synthesis predominates during fetal and neonatal development.
Beyond its canonical role in hematopoiesis, EPO exhibits pleiotropic bioactivities, including angiogenic stimulation via vascular smooth muscle cell proliferation, neuroprotective effects under hypoxic conditions, and modulation of B-cell function.
The recombinant protein retains native conformational integrity, ensuring targeted activation of the EPO receptor (EPOR) to orchestrate tissue-specific responses without off-target interactions, making it invaluable for therapeutic applications in anemia treatment and regenerative medicine.
Specifications
| Specification | Acceptance Criteria | TL-636-0050 | TL-636-0100 |
|---|---|---|---|
| Appearance | Freeze-dried preparation, the form should be white loose body | Compliance | Compliance |
| Identity | The electrophoretic bands should be consistent with the molecular weight of the product | Compliance | Compliance |
| Visible Particle | Should be no visible particle | Compliance | Compliance |
| Moisture | ≤4.0% | 2.0% | 2.9% |
| pH | 6.5~7.5 | 7.3 | 7.3 |
| Purity | >90% / SDS-PAGE | Compliance | Compliance |
| Endotoxin | <0.1EU/μg | <0.1EU/μg | <0.1EU/μg |
| Mycoplasma | Should be negative | Negative | Negative |
| Sterility | No growth | No growth | No growth |
| Biological Activity | Cell proliferation assay with TF-1 cells, specific activity ≥1×106 IU/mg | 3.08×106 IU/mg | — |
Features
-
✔ Glycosylated, Mammalian-Derived EPO
HEK293 expression preserves native glycosylation and EPOR-specific signaling fidelity.
-
✔ Validated High Biological Activity
Demonstrated potency in TF-1 cell proliferation assay (≥1.0 × 10⁶ IU/mg).
-
✔ High Purity with Stringent QC
90% purity by SDS-PAGE with confirmed sterility, mycoplasma negativity, and low endotoxin.
-
✔ Consistent Lot-to-Lot Performance
Controlled moisture, pH, and activity ensure reproducibility in hematopoietic research workflows.
Applications
Erythropoiesis Research
Promotes proliferation and differentiation of erythroid progenitors (CFU-E).
T Cell-Related Studies
Applied as a functional cytokine component in immune cell research systems.
CIK Cell Research
Used in cytokine-induced killer (CIK) cell culture and functional modulation studies.
Regenerative & Angiogenesis Research
Explored for non-hematopoietic roles including angiogenesis and tissue protection under hypoxia.
Stability & Storage
- Lyophilized powder: Stable for 12 months at −80 °C or 6 months at −20 °C when stored in the original sealed container under desiccant.
- Reconstitution: Dissolve in sterile Water for Injection, 0.9% NaCl, or PBS (pH 7.4), maintaining a final concentration ≥100 µg/mL to prevent adsorption.
- Handling: Aliquot to avoid repeated freeze–thaw cycles.
Cautions
• Research Use Only: This product is not intended for diagnostic or therapeutic use.
• Handling: Prepare solutions using sterile technique. Avoid microbial contamination to maintain activity.
• Storage: Follow recommended storage conditions. Repeated freeze–thaw cycles may reduce performance.
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
