Pexidartinib (PLX3397) Purity 99.5%

X-Ray Confirmed Crystal Form for Peak PLX-3397 Activity and Consistency

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Description

Pexidartinib (PLX-3397) is a potent, orally active, and ATP-competitive inhibitor of colony stimulating factor 1 receptor (CSF1R/M-CSFR) and c-Kit, with IC₅₀ values of 20 nM and 10 nM, respectively. It displays 10- to 100-fold selectivity for CSF1R and c-Kit over related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and demonstrates strong anti-tumor activity in research models.

Specification

CAS No. 1029044-16-3
Synonyms PLX3397
Molecular Formula C20H15ClF3N5
Formula Weight 417.81
Purity ≥98%
Formulation A crystalline solid
Solubility DMF: 20 mg/ml
DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml
DMSO: 20 mg/ml
Color
Off-white to light yellow
SMILES ClC1=CC2=C(N=C1)NC=C2CC3=CN=C(NCC4=CN=C(C(F)(F)F)C=C4)C=C3
InChi Code InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
InChi Key JGWRKYUXBBNENE-UHFFFAOYSA-N

 

Features

  • Dual Kinase Inhibitor: Potently inhibits CSF1R and c-Kit with nanomolar activity.

  • High Selectivity: Demonstrates strong selectivity over related kinases, reducing off-target effects in research assays.

  • XRD-Verified Crystal Form: Confirmed high-activity and high-stability crystalline form by X-ray diffraction.

  • Superior Reproducibility: Ensures consistent lot-to-lot performance and reliable experimental results.

  • High Purity: ≥99.5% purity by HPLC for precise and reproducible research applications.

  • Flexible Solubility: Soluble in DMSO and DMF, compatible with common in vitro and in vivo research protocols.

Applications

  • Oncology Research: Study tumor growth, apoptosis, and kinase-driven cancer pathways.

  • Immuno-Oncology Studies: Investigate CSF1R signaling and tumor-associated macrophage modulation.

  • Kinase Signaling Research: Explore CSF1R- and c-Kit-mediated signaling mechanisms.

  • Drug Discovery & Preclinical Research: Evaluate kinase inhibition efficacy and structure-activity relationships.

  • Cell-Based Assays: Assess anti-proliferative and pro-apoptotic effects in relevant cell models.

Crystal Form Verified by X-ray Diffraction (XRD)

PLX-3397 obtained from different suppliers can display different crystalline forms, which may lead to notable variations in biological activity, solubility, stability, and experimental reproducibility.

Biofargo’s PLX-3397 is confirmed by X-ray diffraction (XRD) to be a high-activity and highly stable crystal form, ensuring:

  • Consistent lot-to-lot performance

  • Highly reproducible experimental outcomes

  • Superior biological activity compared with non-verified crystal forms

  • Reliable solubility behavior across assays

For research use only. We do not sell to patients.

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When can I expect my order to ship?

Most orders are filled and shipped within 2-3 business days from the time they are received.

Our standard shipping usually take 2-5 days.

We also provide express shippping for time-sensitive deliveries. 

Email contact@biofargo.com if you have any requirements.

 

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