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X-Ray Confirmed Crystal Form for Peak PLX-3397 Activity and Consistency
$26.00
Sku: BD560570-5
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by July 08, 2026
Description
Pexidartinib (PLX-3397) is a potent, orally active, and ATP-competitive inhibitor of colony stimulating factor 1 receptor (CSF1R/M-CSFR) and c-Kit, with IC₅₀ values of 20 nM and 10 nM, respectively. It displays 10- to 100-fold selectivity for CSF1R and c-Kit over related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and demonstrates strong anti-tumor activity in research models.
Specification
| CAS No. | 1029044-16-3 |
| Synonyms | PLX3397 |
| Molecular Formula | C20H15ClF3N5 |
| Formula Weight | 417.81 |
| Purity | ≥99.5% |
| Formulation | A crystalline solid |
| Solubility |
DMF: 20 mg/ml DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml DMSO: 20 mg/ml |
| Color | Off-white to light yellow |
| SMILES | ClC1=CC2=C(N=C1)NC=C2CC3=CN=C(NCC4=CN=C(C(F)(F)F)C=C4)C=C3 |
| InChi Code | InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29) |
| InChi Key | JGWRKYUXBBNENE-UHFFFAOYSA-N |
Features
- Dual Kinase Inhibitor: Potently inhibits CSF1R and c-Kit with nanomolar activity.
- High Selectivity: Demonstrates strong selectivity over related kinases, reducing off-target effects in research assays.
- XRD-Verified Crystal Form: Confirmed high-activity and high-stability crystalline form by X-ray diffraction.
- Superior Reproducibility: Ensures consistent lot-to-lot performance and reliable experimental results.
- High Purity: ≥99.5% purity by HPLC for precise and reproducible research applications.
- Flexible Solubility: Soluble in DMSO and DMF, compatible with common in vitro and in vivo research protocols.
Applications
- Oncology Research: Study tumor growth, apoptosis, and kinase-driven cancer pathways.
- Immuno-Oncology Studies: Investigate CSF1R signaling and tumor-associated macrophage modulation.
- Kinase Signaling Research: Explore CSF1R- and c-Kit-mediated signaling mechanisms.
- Drug Discovery & Preclinical Research: Evaluate kinase inhibition efficacy and structure-activity relationships.
- Cell-Based Assays: Assess anti-proliferative and pro-apoptotic effects in relevant cell models.
Crystal Form Verified by X-ray Diffraction (XRD)
PLX-3397 obtained from different suppliers can display different crystalline forms, which may lead to notable variations in biological activity, solubility, stability, and experimental reproducibility.
Biofargo’s PLX-3397 is confirmed by X-ray diffraction (XRD) to be a high-activity and highly stable crystal form, ensuring:
- Consistent lot-to-lot performance
- Highly reproducible experimental outcomes
- Superior biological activity compared with non-verified crystal forms
- Reliable solubility behavior across assays
For research use only. We do not sell to patients.
Documents
Frequently Asked Questions
What is Pexidartinib (PLX-3397) mainly used for in research?
Pexidartinib (PLX-3397) is commonly used in laboratory research as a selective inhibitor of CSF1R and c-Kit signaling pathways. It is applied in studies focusing on tumor microenvironment regulation, macrophage activity, kinase signaling mechanisms, and apoptosis-related cellular responses.
How does PLX-3397 achieve its biological activity?
PLX-3397 functions as an ATP-competitive kinase inhibitor, blocking CSF1R and c-Kit signaling. By inhibiting these pathways, it can reduce downstream proliferation and survival signaling in relevant cell models.
How should Pexidartinib (PLX-3397) be dissolved and prepared?
PLX-3397 is typically soluble in DMSO and DMF, which are commonly used solvents for preparing stock solutions. For experimental use, it is recommended to prepare fresh aliquots to maintain stability.
Why do different suppliers show different activity or performance for PLX-3397?
Differences in crystalline form, purity, and manufacturing processes can significantly impact biological activity and reproducibility.
What does “XRD-verified crystal form” mean?
X-ray diffraction (XRD) verification confirms the solid-state crystal structure, ensuring consistent molecular arrangement and improved reproducibility.
What purity level is suitable for cell-based or kinase assays?
For most biochemical and cell-based assays, high-purity compounds (typically ≥99.5%) are preferred to ensure reproducibility and low background interference.
How should PLX-3397 be stored for optimal stability?
Store in a dry, light-protected environment at low temperature. Avoid repeated freeze-thaw cycles.
Is PLX-3397 suitable for in vivo research models?
Yes. It is widely used in preclinical models to study kinase inhibition and tumor microenvironment interactions under research-only conditions.
Where can I find COA and MSDS for this product?
COA and MSDS are provided in the Documents section for batch and safety information.
For laboratory research or industrial use only.
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
