Bcakground Insulin-like Growth Factor I (IGF-I) , also known as Somatomedin C, is the dominant effector of Growth Hormone (GH) and is structurally homologous to Proinsulin. Human IGF-I is synthesized...
IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA....
Bcakground Insulin-like Growth Factor II (IGF-II) is a potent mitogenic growth factor. However, unlike IGF-I which has important postnatal roles, the growth -promoting function of IGF-II is limited to embryonic...
Bcakground Insulin-like growth factor binding protein-3 (IGFBP-3)is one of six members of the insulinlike growth factor (IGF) binding protein superfamily which function to modulate the biological activity of IGF (1)....
Bcakground The hedgehog (hh) gene encoding a secreted protein was originally identified in Drosophila as a segment polarity gene. The vertebrate homologues of Hh comprise several proteins including sonic hedgehog...
Bcakground Interleukin 10 ,also known as cytokine synthesis inhibitory factor (CSIF), is the charter member of the IL-10 family of alpha -helical cytokines that also includesIL-19, IL-20, IL-22, IL-24, and...
Bcakground Interleukin-11 (IL-11) is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27 and IL-31 (1-3). In humans, IL-11 was also independently discovered...
Bcakground Interleukin-12 (IL-12) , also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated...