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Specification
| Full name | PHF21A rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events. |
| Swissprot No | Q96BD5 |
| Gene Accession | BC015714 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or PHF21A antigen-treated (Neutralization experiment) using P103596(PHF21A Antibody) at dilution 1/50 |
| WB Positive control | P103596-WB-1-P |
| WB Recommended dilution | 75 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm and Nucleus |
| IHC positive control | Positive control: Human prostate cancer |
| IHC Recommed dilution | Recommended dilution: 40-200 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P103596-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue or PHF21A antigen-treated (Neutralization experiment) using P103596(PHF21A Antibody) at dilution 1/50
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