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Specification
| Full name | LMNA rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | Lamin A/C is also named as LMNA, or LMN1. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. The lack of lamin A/C can be as a novel marker for undifferentiated embryonic stem cells and lamin A/C expression is as an early indicator of differentiation. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. This protein has 4 isoforms produced by alternative splicing with the molecular weight of 74 kDa, 65 kDa, 70 kDa and 64 kDa. This antibody can recognize 4 isoforms of Lamin A/C. |
| Swissprot No | P02545 |
| Gene Accession | BC000511 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human tonsil tissue or LMNA antigen-treated (Neutralization experiment) using P108012(LMNA Antibody) at dilution 1/60 |
| WB Positive control | P108012-WB-1-P |
| WB Recommended dilution | 74 kDa |
| IHC predicted cell location | Predicted cell location: Nucleus |
| IHC positive control | Positive control: Human colorectal cancer |
| IHC Recommed dilution | Recommended dilution: 100-300 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P108012-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human colorectal cancer tissue or LMNA antigen-treated (Neutralization experiment) using P108012(LMNA Antibody) at dilution 1/60
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We also provide express shippping for time-sensitive deliveries.
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