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Specification
| Full name | EZR/RDX/MSN (phospho-Thr567/Thr564/Thr558) rabbit monoclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit monoclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit monoclonal |
| Target Background | The cytoplasmic peripheral membrane protein encoded by the EZR gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. |
| Swissprot No | P15311/P35241/P26038 |
| Gene Accession | 7430/5962/4478 |
| WB Predicted band size | |
| WB Positive control | P290502-WB-1-P |
| WB Recommended dilution | 69 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm and Cell membrane |
| IHC positive control | Positive control: Human tonsil |
| IHC Recommed dilution | Recommended dilution: 50-100 |
Storage
-20°C, 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA. Avoid repeated freeze-thaw cycles.
WB PIC Description
P290502-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using P290502(EZR/RDX/MSN (phospho-Thr567/Thr564/Thr558) Antibody) at dilution 1/50
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