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$663.00
Sku: Y07901-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 20, 2026
Description
TGF-β3 (Transforming Growth Factor-β3) is a pleiotropic cytokine within the TGF-β superfamily that plays important roles in embryonic development, tissue repair, immune regulation, and cell differentiation. Unlike TGF-β1, which is pro-fibrotic, TGF-β3 exhibits unique functions in wound healing and embryonic development—particularly a stronger anti-scarring capacity. Similar to TGF-β1, TGF-β3 can inhibit the proliferation of many epithelial cells and promote epithelial-to-mesenchymal transition (EMT), which is significant in cancer research and developmental models. In stem cell culture, TGF-β3—often used in combination with BMP—induces the differentiation of mesenchymal stem cells (MSCs) into chondrocytes, making it valuable for cartilage tissue engineering.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y07901 |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured in a cell inhibition assay using TF-1 cells at IL4 presence. The ED50 for this effect is ≤0.2 ng/mL. |
| Accession | P10600 |
| Alternative Names | Transforming growth factor beta-3; TGFB3; TGF-beta-3; Latency-associated peptide; LAP |
| Species | Human |
| Expression System | CHO |
| Mol. Weight | 13 kDa |
| Expression Region | Ala 301-Ser 412 |
| Tag Info | Tag free |
| Formulation | Lyophilized |
| Buffer | Lyophilized from a 0.22 μm-filtered solution containing 100 mM Glycine, 150 mM NaCl, 5% Mannitol and 0.01% Tween 80, pH 4.0. |
| Size | 10μg/50μg/1mg |
| Lead Time | Products are in stock,but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Hematology
Modulates stromal support for hematopoiesis.
Immunology
Participates in immune regulation, less potent than TGF-尾1.
Stem Cell Research
Influences stem cell differentiation and tissue remodeling.
Cell Biology
Regulates ECM deposition, proliferation, and differentiation processes.
Data Figures
Figure 1: Measured in a cell inhibitionn assay using TF-1 cells at IL4 presence. The ED50 for this effect is ≤0.2 ng/mL. The bioactivity of Y07901 was higher than other competing products.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
