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Full name | COMT rabbit polyclonal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | rabbit polyclonal |
Applications | WB, IHC |
Host | Rabbit |
Clone type | rabbit polyclonal |
Target Background | Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. |
Swissprot No | P21964 |
Gene Accession | BC011935 |
WB Predicted band size | |
WB Positive control | P103827-WB-1-P |
WB Recommended dilution | 30 kDa |
IHC predicted cell location | Predicted cell location: Nucleus and Cytoplasm |
IHC positive control | Positive control: Human lung cancer |
IHC Recommed dilution | Recommended dilution: 25-100 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
P103827-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue or COMT antigen-treated (Neutralization experiment) using P103827(COMT Antibody) at dilution 1/25
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