Oligo MW & Extinction Coefficient Calculator

Estimate molecular weight and UV extinction coefficient for a single-stranded DNA oligo from its sequence.

DNA sequence (5' → 3', bases A/T/G/C only)

A260 reading (optional)

Enter an A260 reading to also calculate concentration in µg/mL and pmol/µL.

Molecular weight uses the standard per-base additive formula for a 5'-OH/3'-OH oligo. Extinction coefficient uses the simple base-composition method (sum of individual base coefficients) — this is an approximation, not the more precise nearest-neighbor method used by tools like IDT OligoAnalyzer, and can differ by roughly 10%.

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