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Specification
| Full name | TPPP rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. |
| Swissprot No | O94811 |
| Gene Accession | BC131506 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or TPPP antigen-treated (Neutralization experiment) using P105626(TPPP Antibody) at dilution 1/25 |
| WB Positive control | P105626-WB-1-P |
| WB Recommended dilution | 24 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm or Nucleus |
| IHC positive control | Positive control: Human lung cancer |
| IHC Recommed dilution | Recommended dilution: 25-100 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P105626-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue or TPPP antigen-treated (Neutralization experiment) using P105626(TPPP Antibody) at dilution 1/25
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