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Sku: P113508-50 μl
Categories: Primary Antibodies

Specification

Full name SPRY2 rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. 
Swissprot No O43597
Gene Accession BC015745
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue or SPRY2 antigen-treated (Neutralization experiment) using P113508(SPRY2 Antibody) at dilution 1/200
WB Positive control P113508-WB-1-P
WB Recommended dilution 35 kDa
IHC predicted cell location Predicted cell location: Cytoplasm
IHC positive control Positive control: Human colorectal cancer
IHC Recommed dilution Recommended dilution: 200-400

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P113508-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human colorectal cancer tissue or SPRY2 antigen-treated (Neutralization experiment) using P113508(SPRY2 Antibody) at dilution 1/200

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