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Specification
| Full name | ERBB2 rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. |
| Swissprot No | P04626 |
| Gene Accession | NP_004439 |
| WB Predicted band size | |
| WB Positive control | P112670-WB-1-P |
| WB Recommended dilution | 138 kDa |
| IHC predicted cell location | Predicted cell location: Cell membrane |
| IHC positive control | Positive control: Human breast cancer |
| IHC Recommed dilution | Recommended dilution: 50-200 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P112670-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue or ERBB2 antigen-treated (Neutralization experiment) using P112670(ERBB2 Antibody) at dilution 1/50
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Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
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