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Sku: P290261-50 μl
Categories: Primary Antibodies

Specification

Full name CDH1 rabbit monoclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit monoclonal
Applications WB, IHC, IF
Host Rabbit
Clone type rabbit monoclonal
Target Background This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Swissprot No P12830
Gene Accession 999
WB Predicted band size
WB Positive control P290261-WB-1-P
WB Recommended dilution 97 kDa
IHC predicted cell location Predicted cell location: Cell membrane
IHC positive control Positive control: Human cholangiocarcinoma
IHC Recommed dilution Recommended dilution: 50-100

Storage

-20°C, 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA. Avoid repeated freeze-thaw cycles.

WB PIC Description

P290261-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human cholangiocarcinoma tissue using P290261(CDH1 Antibody) at dilution 1/50

When can I expect my order to ship?

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