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Sku: P100045-50 μl
Categories: Primary Antibodies

Specification

Full name BAX rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Swissprot No Q07812
Gene Accession BC014175
WB Predicted band size
WB Positive control P100045-WB-1-P
WB Recommended dilution 21 kDa
IHC predicted cell location Predicted cell location: Cytoplasm
IHC positive control Positive control: Human cervical cancer
IHC Recommed dilution Recommended dilution: 50-200

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P100045-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue or BAX antigen-treated (Neutralization experiment) using P100045(BAX Antibody) at dilution 1/55

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