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$360.00
Sku: Y02901-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 18, 2026
Description
IL-21 (Interleukin-21) is a pleiotropic cytokine belonging to the common gamma-chain (γc) cytokine family, primarily produced by activated CD4⁺ T cells and natural killer T (NKT) cells. It plays important roles in immune regulation, cell proliferation, differentiation, and functional modulation. In B cell cultures, IL-21 induces plasma cell differentiation and enhances the secretion of IgG and IgM. In T cells, it promotes the proliferation and cytotoxicity of CD8⁺ T cells and NK cells, making it valuable for tumor immunotherapy research, such as in CAR-T cell cultivation. Additionally, IL-21 can suppress regulatory T cell (Treg) function and enhance the anti-tumor activity of effector T cells. In NK cell cultures, it augments killing capacity and IFN-γ secretion, and is widely used in studies related to immune cell therapy.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y02901 |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is ≤ 20 ng/mL. |
| Accession | Q9HBE4 |
| Alternative Names | Interleukin-3; IL-3; Hematopoietic Growth Factor; Mast Cell Growth Factor; MCGF; Multipotential Colony-Stimulating Factor; P-Cell-Stimulating Factor; IL3 |
| Species | Human |
| Expression System | CHO |
| Mol. Weight | 15.9 kDa |
| Expression Region | His25-Ser162 |
| Tag Info | Tag free |
| Formulation | Lyophilized |
| Buffer | PBS, 5% Mannitol and 0.01% Tween 80, pH7.4. |
| Size | 10μg/50μg/1mg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at 2°C to 8°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Hematology
Regulates B cell differentiation and antibody production.
Immunology
Enhances T, B, and NK cell effector functions.
Cell Biology
Regulates cell differentiation and effector programs.
Data Figures
Figure 1: Recombinant Human IL-21 (Cat. No. Y02901) SDS-PAGE under reducing (R) & Non-reducing conditions. The gel was stained with Y02901 SDS-PAGE.
Figure 2: Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is ≤ 20 ng/mL. The bioactivity of recombinant Human IL21 (Cat. No. Y02901) is higher than the other competing product.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
