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$431.00
Sku: Y04201N-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 20, 2026
Description
TGF-β1 (Transforming Growth Factor-β1) is a multifunctional cytokine belonging to the TGF-β superfamily. It inhibits the growth of most epithelial, endothelial, and hematopoietic cells by inducing cell cycle arrest in the G1 phase. In stem cell culture, TGF-β1 can direct the differentiation of mesenchymal stem cells into osteoblasts, chondrocytes, or adipocytes. In organoid culture systems, it regulates extracellular matrix (ECM) formation and influences tissue organization. Additionally, TGF-β1 exhibits immunomodulatory effects by suppressing the activation of T cells, B cells, NK cells, and macrophages, thereby reducing inflammatory responses. In co-culture systems—such as those involving immune and tumor cells—TGF-β1 can help mimic an immune-suppressive microenvironment.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y04201N |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured in a cell inhibition assay using TF-1 cells at IL4 presence. The ED50 for this effect is ≤0.1ng/mL. |
| Accession | P01137 |
| Alternative Names | Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB |
| Species | Human |
| Expression System | CHO |
| Mol. Weight | 12.8 kDa |
| Expression Region | Ala279-Ser390 |
| Tag Info | Tag free |
| Form | Lyophilized |
| Buffer | 0.085% TFA, 30% ACN, 5% Mannitol, pH 2.5. |
| Size | 10μg/50μg/1mg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in 4mM HCL. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Hematology
Regulates hematopoietic stem cell quiescence and lineage balance.
Immunology
Strong immunosuppressive factor, modulating Tregs and inhibiting effector T cells.
Stem Cell Research
Maintains stem cell quiescence and guides differentiation; used in organoid cultures.
Cell Biology
Regulates proliferation, apoptosis, ECM production, and EMT.
Data Figures
Figure 1: Recombinant Human TGF-β1 (Cat. No. Y04201N) SDS-PAGE under reducing (R) & Non-reducing condition. The gel was stained with Y04201.
Figure 2: Measured in a cell inhibition assay using TF-1 cells at IL-4 presence. The ED50 for this effect is ≤0.1 ng/mL. The bioactivity of Y04201N was higher than other competing products.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
