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$394.00
Sku: Y02401-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 20, 2026
Description
IL-7 (Interleukin-7) is a cytokine produced by bone marrow stromal cells, thymic epithelial cells, and other cell types. It belongs to the four-helix bundle cytokine family and exerts its functions primarily by binding to the IL-7 receptor, thereby activating signaling pathways such as JAK-STAT, PI3K-AKT, and MAPK. IL-7 plays an essential role in the immune system, particularly in T cell development, survival, and homeostatic proliferation. In in vitro cultures, IL-7 supports the survival of naïve and memory T cells and helps prevent apoptosis. During early B cell development, it promotes both proliferation and differentiation. In the context of cell therapy—such as CAR-T or TCR-T treatments—IL-7 is often used in combination with other cytokines like IL-15 to enhance T cell expansion and maintain stem-like properties. Furthermore, IL-7 can improve the yield and activity of tumor-infiltrating lymphocytes (TILs) or virus-specific T cells during culture.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y02401 |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured in a cell proliferation assay using NALM-6 human pre-B cells. The ED50 for this effect is ≤30 ng/mL. |
| Accession | P13232 |
| Alternative Names | Interleukin-7; IL-7; IL7 |
| Species | Human |
| Expression System | CHO |
| Mol. Weight | 17.3 kDa |
| Expression Region | Asp26-His177 |
| Tag Info | Tag free |
| Formulation | Lyophilized |
| Buffer | PBS, 5% Mannitol and 0.01% Tween 80, pH7.4. |
| Size | 10μg/50μg/1mg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at 2°C to 8°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Hematology
Supports lymphoid cell development and survival.
Immunology
Maintains T cell homeostasis and immune memory.
Cell Biology
Regulates cell survival and anti-apoptotic signaling.
Data Figures
Figure 1: Recombinant Human IL-7 (Cat. No. Y02401) SDS-PAGE under reducing (R) & Non-reducing conditions. The gel was stained with Y02401 SDS-PAGE.
Figure 2: Measured in a cell proliferation assay using NALM-6 human pre-B cells. The ED50 for this effect is ≤30 ng/mL.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
