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$382.00
Sku: Y02701-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 20, 2026
Description
IL-15 (Interleukin-15) is a pleiotropic cytokine belonging to the common gamma-chain (γc) cytokine family. While structurally similar to IL-2, it exhibits distinct functional properties. It is primarily produced by antigen-presenting cells (such as dendritic cells and macrophages), epithelial cells, and fibroblasts, and acts through activation of the JAK-STAT signaling pathway, predominantly via JAK1/3 and STAT3/5. IL-15 is essential for the survival of memory CD8⁺ T cells and natural killer (NK) cells. In serum-free culture systems, it can substitute for serum by providing crucial survival signals, thereby promoting the persistence and proliferation of T and NK cells while enhancing NK cell cytotoxicity. As a key tool in tumor immunology, infectious immunity, and cell therapy research, IL-15 plays an especially indispensable role in experiments requiring long-term maintenance of immune cell activity.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y02701 |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is ≤0.1 ng/mL，corresponding to a specific bioactivity of ≥ 2 x 107 units/mg. |
| Accession | P40933 |
| Alternative Names | Interleukin-15; IL-15; IL15 |
| Species | Human |
| Expression System | CHO |
| Mol. Weight | 12.7 kDa |
| Expression Region | Asn49-Ser162 |
| Tag Info | Tag free |
| Form | Lyophilized |
| Buffer | PBS, 5% Mannitol and 0.01% Tween 80, pH7.4. |
| Size | 10μg/50μg/1mg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at 2°C to 8°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Hematology
Promotes NK and memory T cell generation.
Immunology
Maintains long-term survival of NK and CD8+ T cells.
Cell Biology
Regulates metabolism, survival, and functional maintenance.
Data Figures
Figure 1: Recombinant Human IL-15 (Cat. No. Y02701) SDS-PAGE under reducing (R) & Non-reducing conditions. The gel was stained with Y02701 SDS-PAGE.
Figure 2: Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is ≤0.5 ng/mL.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
