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$99.00
Sku: TL-105-0010
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 18, 2026
Background
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) is a pivotal glycosylated cytokine functioning extracellularly as a homodimer. Its core function is to stimulate the proliferation and differentiation of hematopoietic stem/progenitor cells into granulocytes and monocytes (which mature into macrophages and dendritic cells).
Leveraging this, GM-CSF finds extensive application in cell and gene therapy. In cell therapy, it is a critical factor for the in vitro expansion of immune cells (e.g., dendritic cells for DC vaccines) and acts as an immune modulator in vivo to activate DCs and T cells, enhancing anti-tumor immunity.
In gene therapy, its encoding gene (located in the chromosome 5q31 region) serves as a potential target, or therapeutic GM-CSF can be delivered via vectors for localized and sustained expression.
Recombinantly produced GM-CSF protein provides an essential tool for these applications, with its potential dual immunomodulatory effects requiring careful evaluation.
Specifications
| Product Details | ||
|---|---|---|
| Parameter | RUO Grade | GMP Grade |
| Catalog Number | TL-105-0010 | GMP-TL105-0200 |
| Synonyms | Interferon-gamma, Interferon-γ, Immune interferon | Interferon-gamma, Interferon-γ, Immune interferon |
| Accession | UniProt P01579 | UniProt P01579 |
| Expressed Region | Gln24–Gln166 | Gln24–Gln166 |
| Tag | C-terminal 6×His-tag | C-terminal 6×His-tag |
| Expression System | HEK293 cells | HEK293 cells |
| Molecular Weight | 17.6 kDa | 17.6 kDa |
| Purity | >90% (SDS-PAGE) | >90% (SDS-PAGE) |
| Endotoxin | <0.1 EU/µg | <0.1 EU/µg |
| Biological Activity | HT-29 cell proliferation inhibition assay, ≥ 1.0 × 107 IU/mg |
HT-29 cell proliferation inhibition assay, ≥ 1.0 × 107 IU/mg |
| Formulation | Lyophilized from PBS (pH 7.4), 6–8% mannitol | Lyophilized from PBS (pH 7.4), 6–8% mannitol |
Features
-
✔
High Purity: This product is purified using advanced chromatographic techniques, achieving a purity level of over 95%, ensuring reliable and reproducible results in experiments.
-
✔
High Biological Activity: Confirmed through multiple activity assays, this IFN-α protein effectively induces antiviral and antiproliferative effects in target cells, making it suitable for a range of research applications.
-
✔
Batch Consistency: Produced with rigorous quality control measures to ensure consistent quality between batches, reducing variability and enhancing experimental reliability.
- ✔ Animal-Free: Manufactured without animal-derived components, adhering to animal-free standards and broadening its applicability for various research purposes.
Applications
Virology
Study the antiviral mechanisms of IFN-α, providing insights into its role in controlling viral infections and developing antiviral therapies.
Immunology
Investigate the immunomodulatory effects of IFN-α on immune cell functions and interactions, contributing to a better understanding of immune responses and potential treatments for immune disorders.
Oncology
Explore the antiproliferative effects of IFN-α on cancer cells, offering valuable information for the development of cancer immunotherapies and treatment strategies.
Cell Culture
Utilize IFN-α to enhance cell culture systems, providing a more controlled environment for studying cellular responses and drug effects.
Stability & Storage
- √ Lyophilized powder: Stable for 12 months at -80°C or 6 months at -20°C when stored inthe original sealed container under desiccant.
- √ Reconstitution: Dissolve in sterile Water for Injection, 0.9% NaCl, or PBS (pH 7.4)maintaining final concentration ≥100 µg/mL to prevent adsorption.
- √ Handling: Aliquot to avoid repeated freeze-thaw cycles.
Cautions
• Research Use Only: This product is not intended for diagnostic or therapeutic use.
• Handling: Follow recommended storage and handling instructions to maintain product stability.
• Support: Contact technical support if assistance is required.
Document
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
