Recombinant Human GM-CSF (CSF2) Cell Biologics

Description

GM-CSF is a hematopoietic growth factor that is produced by endothelial cells, monocytes, fibroblasts and T-lymphocytes following their activation by antigens or mitogens. GM-CSF stimulates the development of macrophages and neutrophils and plays a role in the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. Approximately 90% of the secreted colony stimulating activities are due to GM-CSF. While non-glycosylated and glycosylated GM-CSF show similar activities in vitro, fully glycosylated GM-CSF is biologically more active in vivo compared to its non-glycosylated counterpart. Human and murine GM-CSF are species-specific and therefore, exhibit no cross-reactivity. Recombinant Human GM-CSF is a glycosylated, monomeric protein (contains intra-chain disulfide bonds) that migrates at approximately 25 kDa in a reducing SDS-PAGE.

This product is compatible with cell culture workflows associated with the Cell Biologics system, and is suitable for use in standard cytokine-supplemented media formulations commonly used with Cell Biologics primary cells and immune-related cell models.

It can be used as a general GM-CSF source in Cell Biologics–based experimental setups, including immune cell culture and cytokine-dependent cell maintenance systems.

A related recombinant human GM-CSF protein with full product specifications is also available: Recombinant Human GM-CSF Protein (TL-302-0010)