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$426.00
Sku: Y01421H-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 20, 2026
Description
GDNF (Glial Cell Line-Derived Neurotrophic Factor) is an important neurotrophic factor belonging to the TGF-β superfamily. Initially isolated from a rat glial cell line, it has become a research focus due to its remarkable protective effects on dopaminergic neurons, showing potential therapeutic value especially in the treatment of Parkinson's disease. GDNF is also involved in the cultivation and directed differentiation of stem cells, and is often used in combination with factors such as SHH and FGF8 to induce the differentiation of embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) into dopaminergic neurons.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y01421H |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. The ED50 for this effect is ≤20 ng/mL in the presence of Recombinant Human GDNF R alpha-1. |
| Accession | NP_000505.1 |
| Species | Human |
| Expression System | E. coli |
| Mol. Weight | 15.2 kDa |
| Expression Region | S78-I211 |
| Tag Info | Tag free |
| Formulation | Lyophilized |
| Buffer | Lyophilized from a 0.22 μm-filtered solution containing 20 mM Sodium Citrate, 5% Mannitol, pH2.5. |
| Size | 10μg/50μg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Stem Cell Research
Maintains survival and proliferation of neural stem cells and dopaminergic progenitors.
Cell Biology
Supports neuronal survival, differentiation, and axon guidance.
Data Figures
Figure 1: Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. The ED50 for this effect is ≤20 ng/mL in the presence of Recombinant Human GDNF R alpha -1.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
