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$272.00
Sku: Y00421H-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 22, 2026
Description
BMP-2 (Bone Morphogenetic Protein 2), a member of the transforming growth factor-beta (TGF-β) superfamily, is synthesized in vivo as a precursor protein. Through proteolytic cleavage that removes the signal peptide and propeptide, it yields a mature peptide consisting of 114 amino acid residues. This mature peptide further forms homodimers or heterodimers via dimerization, thereby acquiring full biological activity. BMP-2 stimulates DNA synthesis and cell replication, promoting the directed differentiation of mesenchymal cells into osteoblasts. As a key factor inducing bone and cartilage formation in vivo, BMP-2 is expressed during limb growth, endochondral ossification, early fracture healing, and cartilage repair, playing a critical role in embryonic skeletal development and regenerative repair.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y00421H |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤100 EU/mg by the LAL method. |
| Bioactivity | Measured by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is ＜0.5 ug/ml. |
| Accession | P12643 |
| Species | Human |
| Expression System | E. coli |
| Mol. Weight | 12.9 kDa (monomer) |
| Expression Region | Gln283-Arg396 |
| Tag Info | Tag free |
| Formulation | Lyophilized |
| Buffer | Lyophilized from a 0.22 μm filtered solution containing 0.1 M Acetic acid, 5% Trehalose, pH 3.0. |
| Size | 10μg/50μg/1mg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in 4 mM HCl. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Hematology
Promotes osteogenic differentiation of hematopoietic niche stromal cells.
Immunology
Modulates immune cell maturation and inflammatory responses indirectly.
Stem Cell Research
Induces mesenchymal stem cell osteogenic differentiation and supports tissue engineering.
Cell Biology
Key regulator of bone formation, cell differentiation, and morphogenesis via SMAD1/5/8.
Data Figures
Figure 1: Measured by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is ＜0.5 ug/ml.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
