0 item(s)
View cart
You have no items in your shopping cart.
$350.00
Sku: TL-770-0050
Availability:
QUICK SHIP
In stock & estimated to ship in 1-2 days by March 15, 2026
Description
Brain-Derived Neurotrophic Factor (BDNF) is one of the most widely distributed and extensively studied neurotrophic factors in the mammalian brain.
BDNF is secreted by glutamatergic neurons and glial cells in the brain.
It regulates normal brain functions by binding to and activating TrkB.
BDNF–TrkB signaling promotes the differentiation of cortical progenitor cells into neurons and participates in adult neurogenesis in the hippocampus.
BDNF modulates synaptic transmission and long-term potentiation (LTP) in the hippocampus and other brain regions.
Dysregulation of BDNF signaling is associated with multiple disorders, including Alzheimer’s disease (AD), depression, and schizophrenia.
Specifications
| Parameter | Specification |
|---|---|
| Expression Host | E. coli |
| Synonyms | Abrineurin; BDNF; ANON2; BULN2 |
| Protein Sequence | Amino acid sequence: His129–Arg247 of human BDNF (UniProt ID: P23560-1) |
| Molecular Weight | Predicted molecular weight is 13.51 kDa |
| Purity | >95%, analyzed by SDS-PAGE and HPLC |
| Endotoxin | <0.01 EU/μg |
| Purification Method | Chromatographic purification |
| Appearance | White lyophilized powder |
| Activity | Refer to COA for details |
Features
-
✔
Recombinant Human BDNF Protein (E. coli Expression)
Produced in E. coli and purified through chromatographic methods, ensuring high purity and consistent protein quality suitable for neuronal research applications.
-
✔
Defined Human BDNF Functional Fragment
Corresponds to the His129–Arg247 region of human BDNF with a predicted molecular weight of approximately 13.51 kDa.
-
✔
Ultra-Low Endotoxin Preparation
Endotoxin level <0.01 EU/μg, supporting sensitive cell culture systems and minimizing inflammatory interference during neuronal studies.
-
✔
High-Purity Lyophilized Protein Format
Purity >95% verified by SDS-PAGE and HPLC, supplied as a white lyophilized powder for stable storage and reproducible experimental performance.
Applications
Neuronal Differentiation Research
BDNF activates TrkB signaling to promote differentiation of cortical progenitor cells into neurons.
Adult Neurogenesis Studies
Supports investigation of hippocampal neurogenesis and neuronal maturation in brain development models.
Synaptic Plasticity & LTP Research
Widely used to study synaptic transmission and long-term potentiation (LTP) mechanisms in hippocampal and neural circuit models.
Stem Cell Culture Systems
Applicable for stem cell culture environments including iPSC and MSC research systems.
Storage
Store below -20°C
Instructions
Reconstitute in distilled water to a concentration >100 μg/mL. Following reconstitution, the product is stable for 3-6 months when stored at -80°C, or for 2-7 days when stored at 2-8°C.
Precautions
This product is only suitable for in vitro cell culture and cannot be used directly in clinical treatment.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
