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$180.00
Sku: TL-910-0050
Availability:
QUICK SHIP
In stock & estimated to ship in 1-2 days by March 15, 2026
Description
Activin A is a dimeric glycoprotein belonging to the TGF-β superfamily. It plays crucial roles in various physiological processes, including embryonic differentiation, trophoblast invasion during early pregnancy, and neuroprotection under hypoxic conditions.
Additionally, Activin A is involved in bone formation and regeneration, contributes to joint inflammation in rheumatoid arthritis, and mediates pathogenic mechanisms in the respiratory system.
Activin A signals through a complex of two type I and two type II serine/threonine kinase receptors. Upon ligand binding, these receptors activate their kinase activity and phosphorylate the intracellular mediators SMAD2 and SMAD3.
The phosphorylated SMADs then form a heteromeric complex with SMAD4. This complex translocates to the nucleus, where it regulates the transcription of target genes.
Specifications
| Parameter | Specification |
|---|---|
| Expression Host | HEK293 cells |
| Synonyms | Activin A; INHBA |
| Protein Sequence | Amino acid sequence: Gly311–Ser426 of human Activin A (UniProt ID: P08476) |
| Molecular Weight | Predicted molecular weight is 12.97 kDa |
| Purity | >95%, analyzed by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1 EU/μg |
| Purification Method | Chromatographic purification |
| Appearance | White lyophilized powder |
| Activity | Refer to COA for details |
Features
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HEK293-Expressed Activin A (Gly311–Ser426)
Recombinant human Activin A corresponding to Gly311–Ser426 of human INHBA, expressed in HEK293 cells with a predicted molecular weight of 12.97 kDa.
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High Purity Chromatographic Preparation
Purity >95% determined by SDS-PAGE under reducing conditions following chromatographic purification.
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Low Endotoxin Profile
Endotoxin level <0.1 EU/μg supporting sensitive cell culture applications.
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Defined Lyophilized Protein Format
Supplied as a white lyophilized powder with consistent electrophoretic migration (~14–15 kDa reducing conditions).
Applications
MSC Differentiation Studies
Used to regulate mesenchymal stem cell differentiation and signaling processes in vitro.
iPSC Culture & Lineage Specification
Supports pluripotent stem cell signaling pathways involved in differentiation and developmental modeling.
SMAD2/SMAD3 Signaling Research
Activates type I and type II serine/threonine kinase receptor complexes leading to SMAD2/3 phosphorylation and downstream transcriptional regulation.
Developmental Biology Models
Applied in studies of embryonic differentiation, trophoblast invasion, and hypoxia-related cellular responses.
Instructions
Centrifuge before reopening the tube. Dissolve the lyophilized protein in 4 mM HCl. It is recommended to reconstitute the protein to a concentration greater than 100 μg/mL. After reconstitution, the protein can be stored at -80°C for 3-6 months and at 2-8℃ for 2-7 days. For optimal storage, aliquot the protein and minimize freeze-thaw cycles.
Precautions
This product is only suitable for in vitro cell culture and cannot be used directly in clinical treatment.
Storage
Store below -20°C
Document
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
