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Magnetic Beads for High-Sensitivity Cell-Free DNA Extraction from Plasma and Serum
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Sku: NBF208-100mL
Rebeads CfDNA Special D Cell-Free DNA Extraction Magnetic Beads
For Research Use Only (RUO)
This product is intended for research use only and is not intended for diagnostic or therapeutic use.
Description
Cell-free DNA (cfDNA) refers to short, fragmented DNA molecules that are released into the bloodstream and other bodily fluids following cell death (apoptosis or necrosis). These fragments, typically ranging from 160 to 200 base pairs in length, provide a non-invasive window into the physiological and pathological state of the body.
The analysis of cfDNA, particularly the subset derived from tumors known as circulating tumor DNA (ctDNA), has revolutionized diagnostic medicine. Its key applications encompass:
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Non-Invasive Prenatal Testing (NIPT): The detection of fetal cfDNA in maternal plasma allows for the early screening of chromosomal aneuploidies without any risk to the fetus.
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Liquid Biopsy in Oncology: This is a transformative approach for cancer management. It enables early cancer detection, identification of targetable mutations for personalized therapy, real-time monitoring of treatment response, and early detection of minimal residual disease (MRD) and recurrence.
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Transplant Monitoring: In organ transplant recipients, the quantification of donor-derived cfDNA serves as a highly sensitive, non-invasive biomarker for assessing graft rejection.
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Research and Emerging Diagnostics: cfDNA analysis is being actively explored in other areas, including the study of autoimmune diseases and sepsis.
As a cornerstone of liquid biopsy, cfDNA analysis provides a powerful tool for precision medicine, offering critical insights that were previously inaccessible without invasive procedures.
Our Rebeads CfDNA Special D Cell Free DNA Extraction Magnetic Beads are engineered for the highly efficient and reliable isolation of short-fragment, low-concentration cfDNA from plasma, serum, and other liquid biopsies. Utilizing a specialized surface chemistry, these beads demonstrate superior binding affinity for dsDNA and ssDNA across a wide size range, ensuring maximum recovery of the critical 160–180 bp fraction that is rich in biological information. This technology is the cornerstone for robust and reproducible liquid biopsy workflows, enabling downstream applications in non-invasive prenatal testing (NIPT), cancer early detection, and transplant monitoring.
Specifications
| Art. No. | NBF208 |
| Appearance | Dark Brown To Black Liquid, Slight Odor. |
| Grain Size | 300 nm |
| Concentration | 50 mg/mL |
| Magnetic Reaction Time | < 30 s |
| Sediment Time | > 5 min |
| Application | Serum/plasma Free DNA/RNA |
| Storage Condition | 2-8 ℃, Protected From Light. Do Not Freeze. |
| Shelf Life | 24 months |
| Package | 50 / 100 / 500 / 1000 mL |
| Free Sample | Available |
| Highlight | Special D Cf-DNA Extraction, Cell Free DNA Purification Exceptional Purity, Exceptional Purity Cf-DNA Extraction |
Series Selection Guide
| Parameter | cfDNA Special A | cfDNA Special B | cfDNA Special C | cfDNA Special D |
| Catalog No. | NBF205 | NBF206 | NBF207 | NBF208 |
| Particle Size | 300 nm | 300 nm | 300 nm | 300 nm |
| Concentration | 50 mg/mL | 50 mg/mL | 100 mg/mL | 50 mg/mL |
| Storage Buffer | Ultra pure water | |||
| Shelf Life | 48 months from date of manufacture | |||
| Matrix | Silica magnetic beads | |||
| Applications | Cell-free DNA extraction | Cell-free DNA extraction | Cell-free DNA extraction | Cell-free DNA extraction |
| Suitable For | Serum/plasma cell-free DNA | Serum/plasma cell-free DNA | Serum/plasma cell-free DNA | Serum/plasma cell-free DNA |
| Remarks | For research use only | |||
Features
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Optimized for Short Fragments: Superior recovery efficiency for short, fragmented cfDNA, minimizing the loss of critical biomarkers.
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High Sensitivity & Yield: Designed for maximum yield from low-input and low-concentration samples, which is essential for liquid biopsy applications.
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Exceptional Purity: Effectively removes contaminants such as proteins, salts, and cellular genomic DNA, providing clean cfDNA ideal for sensitive downstream assays like NGS and dPCR.
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Robust & Automation-Ready: Exhibits excellent chemical stability and dispersion, ensuring batch-to-batch consistency and seamless integration into automated, high-throughput nucleic acid extraction systems.
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Rapid Workflow: Streamlines the extraction process, reducing hands-on time and enabling quick turnaround from sample to analysis.
This product is an indispensable tool for clinical researchers and diagnostic developers who require the highest standards of performance in their cfDNA analysis pipeline.
Extraction Procedure
Magnetic Beads Selection Guide
Precautions
- Prevent Agglomeration: Avoid freezing and drying.
- Ensure Proper Resuspension: Vortex before use.
- Color Variation is Normal.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
