Rapamycin 99%

Description

Rapamycin was used as a kind of original antifungal antibiotic, which is produced by Streptomyces hygroscopicus. Now it has been used in the prevention of transplant rejection because of its immunosuppressive effect.  It also exhibits activity against several transplantable tumors and slightly activity to inactive against leukemias. The immunosuppressive effect of Rapamycin is exerted by inhibiting the activation and proliferation of T cells. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle.

Specifications

Features

• High Purity (≥99%)

  Ensures reliable and reproducible results in sensitive biochemical and cellular assays.

• Potent mTOR Pathway Inhibitor

  Forms a complex with FKBP12 to regulate key enzymes involved in cell cycle progression.

• Well-Characterized Biological Activity

  Demonstrates strong inhibitory activity in cellular models, including HEK 293 cells.

• Excellent Solubility

  Readily soluble in DMSO and ethanol for convenient preparation of stock solutions.

• Research-Grade Quality

  Suitable for advanced studies in immunology, oncology, and signal transduction.

Applications

• mTOR signaling pathway research

• Immunology and T-cell activation studies

• Cancer and tumor biology research

• Cell cycle and proliferation analysis

• Mechanistic studies in molecular and cellular biology

Documents

MSDS

COA

Data Sheet