Phosphoramidon

Description

Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.

Specifications

Grade	Ultra Pure
Formula	C23H34N3O10P
MW	543.49
CAS	36357-77-4
Appearance	White to Slightly yellow powder
c Optical Rotation [α]20D 1% water	-35~-27°
Loss on Drying	<5.0%
Activity (IC50) (thermolysin/casein, pH 7.5, 37oC)	Report
Thin Layer Chromatography	Report
Storage	Store frozen (-15 ~ -20℃). Keep dry. Warm to room temperature before opening

 

Documents

COA

References

[1]. Umezawa S, , et al. A new microbial metabolite phosphoramidon (isolation and structure). Tetrahedron Letters, 1972, 13(1): 97-100.

[2]. Suda H, et al. A thermolysin inhibitor produced by actinomycetes: phosphoramidon. The Journal of antibiotics, 1973, 26(10): 621-623.

[3]. Kukkola PJ, et al. Differential structure-activity relationships of phosphoramidon analogues for inhibition of three metalloproteases: endothelin-converting enzyme, neutral endopeptidase, and angiotensin-converting enzyme.J CardiovascPharmacol. 1995;26Suppl 3:S65-8. [Content Brief]