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Bcakground
Leptin is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development.
Specifications
| Synonyms | LEP; leptin (murine obesity homolog); leptin (obesity homolog, mouse); Leptin; OB; Obese protein. |
| Accession # | P41160 |
| Source | Human embryonic kidney cell, HEK293-derived mouse Leptin protein |
| Val22-Cys167 | |
| Predicted Moleucular weight | 41.8 kDa |
Components and Storage
| Formulation | Solution protein |
| Dissolved in sterile PBS buffer | |
| This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening | |
| Storage and Stability | Avoid repeated freeze-thaw cycles |
| It is recommended that the protein be aliquoted for optimal storage | |
| 12 months from date of receipt, -20 to -70 as supplied | |
| Shipping | Shipping with dry ice |
Quality
| Purity | ≥95%, determined by SDS-PAGE |
| Endotoxin Level | ＜0.01 EU per 1 µg of the protein by the LAL method |
| Activity | Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human Leptin R. The EC50 for this effect is 0.075-0.45 ng/mL |
SDS-PAGE
Bioactivity
Documents
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Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
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