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BAF; Hematopoietin-1; IL1 alpha; IL-1 alpha; IL1; IL1A; IL-1A; IL1-ALPHA; IL1F1; IL-1F1; IL1F1hematopoietin-1; interleukin 1, alpha; interleukin-1 alpha; LAF; LEM; preinterleukin 1 alpha; pro-interleukin-1-alpha
$198.00
Sku: RP613-10UG
Bcakground
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6, and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.
Reference
1. Nicklin MJ,et al. (1994)Genomics. 19(2):382-4.
2. March CJ, et al. (1985) Nature. 315(6021):641-7.
3. Bankers-Fulbright JL, et al. (1996) Life Sci. 59(2):61-83.
4. Dinarello CA, et al. (1997) Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.
Specifications
| Synonyms | IL1 alpha; IL-1 alpha; IL1; IL1A; IL-1A; IL1-ALPHA; IL1F1; IL-1F1; IL1F1hematopoietin-1 |
| Accession # | P01582 |
| Source | Human embryonic kidney cell, HEK293-derived mouse IL-1a protein |
| Ser113-Ala271 | |
| Predicted Moleucular weight | 18.0 kDa |
Components and Storage
| Formulation | Solution protein |
| Dissolved in sterile PBS buffer | |
| This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening | |
| Storage and Stability | Avoid repeated freeze-thaw cycles |
| It is recommended that the protein be aliquoted for optimal storage | |
| 12 months from date of receipt, -20 to -70 °C as supplied | |
| Shipping | Shipping with dry ice |
Quality
| Purity | > 95%, determined by SDS-PAGE |
| Endotoxin Level | <0.010 EU per 1 ug of the protein by the LAL method |
| Activity | Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells |
| The EC50 for this effect is 0.1-2 pg/mL |
SDS-PAGE
Bioactivity
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
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