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Mouse BHR1interleukin-13; Mouse IL13; mIL-13; IL-13MGC116788; interleukin 13; MGC116786; NC30; P601
$198.00
Sku: RP610-10UG
Bcakground
Interleukin-13 (IL-13) , is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergic asthma and atopy. It is secreted by Th1 and Th2 CD4+ T cells, NK cells, visceral smooth muscle cells, eosinophils, mast cells, and basophils (1 - 3). IL-13 circulates as a monomer with two and rat (6, 7). IL-13 has diverse activities on numerous cell types (8). On macrophages, IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances. On B cells, IL-13 induces immunoglobulin class switching to IgE, upregulates the expression of MHC class II, CD71, CD72 internal disulfide bonds that contribute to a bundled four alpha -helix configuration (4, 5). Mature mouse IL-13 shares 57%, 75%, and 58% amino acid sequence identity with human, rat, and rhesus IL-13, respectively. Despite the low homology, it exhibits cross-species activity between human, mouse, , and CD23, and costimulates proliferation. IL-13 upregulates IL-6 while downregulating IL-1 and TNF-alpha production by fibroblasts and endothelial cells.
Reference
1. Wills-Karp, M. (2004) Immunol. Rev. 202:175.
2. Nakajima, H. and K. Takatsu (2007) Int. Arch. Allergy Immunol. 142:265.
3. Brown, K.D. et al. (1989) J. Immunol. 142:679.
4. Moy, F.J. et al. (2001) J. Mol. Biol. 310:219.
5. Eisenmesser, E.Z. et al. (2001) J. Mol. Biol. 310:231.
6. Ruetten, H. and C. Thiemermann (1997) Shock 8:409.
7. Lakkis, F.G. et al. (1997) Biochem. Biophys. Res. Commun. 235:529.
8. Wynn, T.A. (2003) Annu. Rev. Immunol. 21:425.
Specifications
| Synonyms | ALRHMGC116789; BHR1interleukin-13; IL13; IL-13; IL-13MGC116788; interleukin 13 |
| Accession # | P20109 |
| Source | Human embryonic kidney cell, HEK293-derived mouse IL-13 protein |
| Ser26-Phe131 | |
| Predicted Moleucular weight | Ser26-Phe131 |
Components and Storage
| Formulation | Solution protein |
| Dissolved in PBS buffer | |
| This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening. | |
| Storage and Stability | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| It is recommended that the protein be aliquoted for optimal storage. | |
| 12 months from date of receipt, -20 to -70 °C as supplied. | |
| Shipping | Shipping with dry ice. |
Quality
| Purity | > 95%, determined by SDS-PAGE. |
| Endotoxin Level | <0.010 EU per 1 ug of the protein by the LAL method. |
| Activity | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. |
| The EC50 for this effect is 0.5-1.5 ng/mL. |
SDS-PAGE
Gel filtration
Bioactivity
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
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