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Human Transforming growth factor beta-2 proprotein;Cetermin Glioblastomaderived T-cell suppressor factor1 Short name: G-TSF
$198.00
Sku: RP520-10UG
Bcakground
TGF-beta 2 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure . TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition . Each TGF-beta isoform has some non‑redundant functions; the TGFB2 gene, which encodes transforming growth factor β2 (TGFβ2), making it an obvious candidate gene for this aneurysm phenotype with MFS- and LDS-like features.Human TGF‑ beta 2 cDNA encodes a 414 amino acid (aa) precursor that contains a 20 aa signal peptide and a 394 aa proprotein . A furin‑like convertase processes the proprotein to generate an N‑terminal 282 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 2 (1-5).
Specifications
| Synonyms | BSC-1 cell growth inhibitor; cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; MGC116892; polyergin; TGFB2; TGFbeta 2; TGF-beta 2; TGF-beta2; TGF-beta-2; transforming growth factor beta-2; transforming growth factor, beta 2 |
| Accession # | P61812 |
| Source | HEK293 |
| Ala303-Ser414 | |
| Predicted Moleucular weight | 12.7 kDa (monomer) |
Components and Storage
| Formulation | Solution protein |
| Dissolved in sterile 20 mM sodium citrate(pH=2.5) buffer . | |
| This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening. | |
| Storage and Stability | Avoid repeated freeze-thaw cycles. |
| It is recommended that the protein be aliquoted for optimal storage. | |
| 12 months from date of receipt, -20 to -70℃ as supplied | |
| Shipping | Shipping with dry ice |
Quality
| Purity | > 95%, determined by SDS-PAGE. |
| Endotoxin Level | ＜0.10 EU per 1 ug of the protein by the LAL method |
| Activity | Measured by the(CAGA)12-luciferase reporter assay |
| The EC50 for this effect is 0.69ng/mL |
SDS-PAGE
Bioactivity
Documents
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