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FIL1 epsilon; FIL1; FIL1(EPSILON); FIL1E; IL-1 epsilon; IL1(EPSILON); IL1E; IL-1E; IL-1F6 (FIL-1-epsilon); IL1F6; IL-1F6; IL36 alpha; IL-36 alpha; IL36A; interleukin 1 family, member 6 (epsilon); interleukin 1, epsilon; Interleukin 36, Alpha; Interleukin-1 epsilon; interleukin-1 family member 6; Interleukin-36 Alpha
$198.00
Sku: RP380-10UG
Human IL-36 alpha, previously called IL-1F6 and FIL1 epsilon (family of IL-1 member epsilon), is a member of the IL-1 family. IL-36 alpha is an 18 22 kDa, 158 amino acid (aa) intracellular and secreted protein that contains no signal sequence, no prosegment and no potential from N linked glycosylation sites. It can be released in response to LPS and the cell ATP induced activation of the P2X7 receptor. It is expressed by monocytes, B and T cells. The receptor for IL 36 alpha is a combination of IL 1 Rrp2 (also called IL1RL2 or IL 1 R6), mainly found in epithelia and keratinocytes, and the widely expressed IL 1 RAcP. IL-36 alpha is present in kidney tubule epithelia, and it is highly expressed in intubulointerstitial lesions in mouse models of chronic glomerulonephritis, lupus nephritis and diabetic nephritis (1-5).
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