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Bcakground
Interleukin-3 (IL-3) is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells. IL3/IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation, and apoptosis. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
Reference
1. Meyer CG, et al. (2011) Hum Mol Genet. 20(6):1173-81.
2. Zambrano A, et al. (2010) Curr Alzheimer Res. 7(7):615-24.
3. Dentelli P, et al. (2011) Oncogene. 30(50):4930-40.
Specifications
| Synonyms | Human IL3; IL3; IL-3; recombinant IL3; interleukin-3; Mast cell growth factor |
| Accession # | AAC08706 |
| Source | Human embryonic kidney cell, HEK293-derived human IL3 protein |
| Ala20-Phe152 | |
| Predicted Moleucular weight | 15.1 kDa |
Components and Storage
| Formulation | Solution protein. |
| Dissolved in sterile PBS buffer. | |
| This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening. | |
| Storage and Stability | Avoid repeated freeze-thaw cycles |
| It is recommended that the protein be aliquoted for optimal storage. | |
| 12 months from date of receipt, -20 to -70 °C as supplied. | |
| Shipping | Shipping with dry ice. |
Quality
| Purity | > 95%, determined by SDS-PAGE. |
| Endotoxin Level | <0.010 EU per 1 ug of the protein by the LAL method. |
| Activity | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. |
| The EC50 for this effect is 0.01-0.08 ng/mL. |
SDS-PAGE
Gel filtration
Bioactivity
Documents
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