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IL23A; Interleukin 23 Subunit Alpha; SGRF; IL23P19; IL-23A; IL-23; P19; Interleukin-Six, G-CSF Related Factor
$198.00
Sku: RP882-10UG
Bcakground
Interleukin 23 is a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
Specifications
| Synonyms | IL-23 p19/IL-12 p40; IL23; IL-23; IL-23p19/IL-12p40 |
| Accession # | p40 (P29460) & p19 (AAG37232) |
| Source | Human embryonic kidney cell, HEK293-derived Human IL-23 proteir p40(Ile23-Ser328) & p19 (Arg20-Pro189). |
| Predicted Moleucular weight | 36.5 kDa (p40) & 18.5 kDa (p19). |
Components and Storage
| Formulation | Solution protein |
| Dissolved in sterile PBS buffer | |
| This solution can be diluted into other aqueous buffers. Centrifuge the via prior to opening. | |
| Storage and Stability | Avoid repeated freeze-thaw cycles. |
| It is recommended that the protein be aliquoted for optimal storage. 12 months from date of receipt, -20 to -70 C as supplied. | |
| Shipping | Shipping with dry ice. |
Quality
| Purity | >95%, determined by SDS-PAGE. |
| Endotoxin Level | <0.01 EU per 1 ug of the protein by the LAL method. |
| Activity | Measured by its ability to induce IL-17 secretion by mouse splenocytes. The EC50 for this effect is 0.25 pg/mL. |
SDS-PAGE
Bioactivity
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
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