Bcakground Stem cell factor (SCF) , also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type...
LAG-3 (Lymphocyte activation gene-3), designated CD223, is a 70 kDa type I transmembrane protein that is a member of the immunoglobulin superfamily (IgSF). Human LAG-3 cDNA encodes 525 amino acids...
Bcakground Flt-3 Ligand(FLT3L)is an alpha-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages (1-3). Mature mouse Flt-3 Ligand consists of a 161 amino acid (aa) extracellular domain (ECD)...
Most cell types express three sizes of receptors for TGF-beta. These are designated type I (53 kDa), type II (70-85 kDa), and type III (250-350 kDa). The type II receptor...
Bcakground Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs) (1, 2). Secreted Noggin probably remains close to the cell surface due to its...
GPC (glypicans) are a family of heparan sulfate proteoglycans that are attached to the cell surface by a glycosylphosphatidylinositol anchor. Mutations in GPC3 cause a rare disorder in humans, Simpson-Golabi-Behmel...
Bcakground Oncostatin M (OSM)is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that...
VEGF is a potent growth factor that promotes both angiogenesis and vascular permeability. It acts on endothelial cells by signaling primarily through two VEGF receptors, VEGF R1 (also called Flt-1)...