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Specifications
| Grade | Ultra Pure |
| Formula | C20H38N6O4•0.5H2SO4 |
| MW | 426.55 • 49.04 |
| CAS | 103476-89-7 |
| Appearance | White amorphous powder |
| Optical rotation (2%, water) [α] 20D |
Report IR spectrum conforms to reference spectrum |
| Storage | -20℃. Keep dry. Warm to room temperature before opening |
Biochem/physiol Actions
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)
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