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Description
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production.
In Vitro
Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death.
Specification
| Molecular Weight | 352.28 |
| Purity | 98% |
| Formula | C11H14FN2O6PS |
| CAS No. | 1374663-29-2 |
| Appearance | Solid |
| Color | White to light yellow |
| SMILES | O=C(N)C1=CC=C[N+]([C@@H]2O[C@H](COP([O-])(O)=S)[C@@H][C@@H]2F)=C1 |
| Storage |
-20°C, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended. |
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