Background

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described.

Specification

Full name	VEGFA rabbit polyclonal antibody
Alternative names	VPF; VEGF; MVCD1
Reactivity	Human
Applications	WB, IHC
Host	Rabbit
Clone type	rabbit polyclonal
Conjugate	Unconjugate
Swissprot No	P15692
Gene Accession	NP_001020537
WB Predicted band size	27 kDa
WB Positive control	Hela cell lysate
WB Recommended dilution	500-2000
IHC predicted cell location_1	Predicted cell location: Cytoplasm
IHC positive control_1	Positive control: Human liver cancer
IHC Recommed dilution	Recommended dilution: 50-200

Application

Western blot analysis of extracts from Hela cell lysate using P113113(VEGFA Antibody) at dilution 1/600

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue or VEGFA antigen-treated (Neutralization experiment) using P113113(VEGFA Antibody) at dilution 1/50

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

VEGFA rabbit polyclonal antibody