Description

Fibroblast growth factor 4 (FGF4) is a member of the FGF family, playing crucial roles in embryonic development, cell proliferation, and differentiation. It promotes the proliferation of neural stem cells and induces neuronal differentiation in the postnatal brain.

In the context of metabolic research, FGF4 has been implicated in liver homeostasis and glucose regulation. Studies indicate that the loss of hepatic FGF4 in animal models can exacerbate high-fat diet-induced steatosis and liver injury.

Furthermore, similar to FGF1, FGF4 exhibits blood glucose-lowering effects. Long-term treatment with recombinant FGF4 (rFGF4) has been shown to improve insulin resistance and inhibit adipose tissue macrophage infiltration and inflammation.

This product is suitable for stem cell research, neurobiology, and metabolic disease-related studies in vitro.

Specifications

Parameter	Specification
Expression Host	E. coli
Synonyms	HBGF-4; HST; HST-1; HSTF1; K-FGF; KFGF
Protein Sequence	DNA sequence encoding human FGF4 (NP_001998.1 Ser54–Leu206) expressed in E. coli
Molecular Weight	Predicted molecular weight is 16.92 kDa
Purity	>95%, analyzed by SDS-PAGE and HPLC
Endotoxin	<0.1 EU/μg
Purification Method	Chromatographic purification
Appearance	White lyophilized powder
Activity	Refer to COA for details

Features

✔ E. coli–Expressed Human FGF4 (Ser54–Leu206)
Recombinant human FGF4 corresponding to Ser54–Leu206, expressed in E. coli with a predicted molecular weight of 16.92 kDa.
✔ High Purity Chromatographic Preparation
Purity >95% verified by SDS-PAGE and HPLC following chromatographic purification.
✔ Low Endotoxin Profile
Endotoxin level <0.01 EU/μg supporting sensitive in vitro cell culture applications.
✔ Defined Lyophilized Protein Format
Supplied as a white lyophilized powder with verified identity and consistent electrophoretic characteristics.

Applications

Neural Stem Cell Proliferation Research

Promotes proliferation of neural stem cells and supports neuronal differentiation studies.

Stem Cell Culture Studies

Applied in stem cell culture systems including MSC and iPSC-related research.

Metabolic Disease Models

Used in studies investigating liver homeostasis, glucose regulation, and insulin resistance mechanisms.

Cell Proliferation & Differentiation Studies

Supports research on cellular proliferation and differentiation pathways associated with the FGF signaling family.

MSC, iPSCs

Instructions

Reconstitute with sterile water. The recommended concentration is greater than 100 μg/mL. It is recommended to reconstitute at a concentration of 250 μg/mL. Please aliquot the protein to avoid repeated freezing and thawing.

Precautions

This product is only suitable for in vitro cell culture and cannot be used directly in clinical treatment.

Storage

-20℃

Documents

📄 TL-782 Data Sheet 📄 TL-782 SDS 📄 TL-782 COA

Recombinant Human FGF4 Protein