Description

PARP1 Rabbit Polyclonal Antibody

PARP1 Rabbit Polyclonal Antibody is a research-use antibody suitable for Western Blot (WB) and Immunohistochemistry (IHC) applications. The antibody targets PARP1, a chromatin-associated poly(ADP-ribosyl)transferase involved in DNA-dependent modification of nuclear proteins.

Specifications

Item	Data
Product Name	PARP1 Rabbit Polyclonal Antibody
Size	50 μL / 100 μL
Reactivity	Not specified
Applications	WB, IHC
Host Species	Rabbit
Clonality	Polyclonal
SwissProt No.	P09874
Gene Accession	NP_001609
WB Predicted Band Size	113 kDa
WB Recommended Dilution	1:500–1:2000
IHC Predicted Cell Location	Nucleus
IHC Positive Control	Human Breast Cancer
IHC Recommended Dilution	1:25–1:100
Storage Conditions	-20°C, pH 7.4 PBS, 0.05% NaN3, 40% Glycerol

Applications

Western Blot (WB)
Immunohistochemistry (IHC)

Target Background

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of important cellular processes such as differentiation, proliferation, tumor transformation, and the molecular events involved in recovery from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia and may participate in the pathophysiology of type I diabetes.

Validation Data

WB PIC Description: P106401-WB-1-P

IHC PIC Description: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using P106401 (PARP1 Antibody) at dilution 1:20.

Note: The IHC validation image was generated at 1:20 dilution. The recommended IHC dilution range is 1:25–1:100.

PARP1 rabbit polyclonal antibody