Description

Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver.[1] NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival.[2] NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.

Specification

Grade	Reagent
Formula	C₆H₆N₂O
MW	122.1
CAS	98-92-0
Appearance	White crystalline or powder
Identification	Complies
Melting Point	128 - 131℃
Loss on Drying	≤0.5%
Residue on ignition	≤0.1%
Heavy Metals	≤0.003%
Readily carbonizable substances	≤ Control Solution A
Organic volatile impurities	Complies
Residual solvents	Complies
Assay	98.5-101.5%
Storage	18~25℃

Application

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.

Documents

COA

SDS