Description

Shrimp hemocyanin (SHC), a highly soluble hemocyanin from the Penaeus vannamei (P. vannamei) , is used as a substitute for KLH. Similar to KLH, SHC serves as a carrier protein for conjugation of hapten (including peptides, nucleic acids, drugs, or toxins). The conjugates would make these haptens highly immunogenic. The immunogenicity of SHC is comparable to KLH. However, the solubility is significantly higher, especially after hapten conjugation. Thus, SHC is advantageous for antibody or vaccine generation (reference).

Specification

Hemocyanin (Non-activated)

Catalog #	Size
HW101S	10 mg
HW101	100 mg
HW101L	100 mg×10

Hemocyanin (SMCC activated)

Catalog #	Size
HW102S	2 mg
HW102	10 mg
HW102L	100 mg

Features

Highly immunogenic ：SHC owns the comparable immunogenicity to KLH
High-yield conjugation：Conjugation efficiency higher than KLH
Excellent solubility：SHC is more soluble than KLH , and is compatible with poorly soluble haptens
Highly purity：Purity ≥ 98%
Excellent performance：Verified through hundreds of antibody generation test
High cost-performance ratio：The price is lower than KLH

SHC could be used for rabbit polyclonal antibody generation

Peptides targeting the indicated proteins were designed and conjugated to SHC. Rabbit serum was harvested 30 days after the first immunization.

A Confirmation of the rabbit serum application in WB detection. Of note, equal cell numbers were loaded.

B Confirmation of the rabbit serum application in IHC detection. Various organs were used for test.

SHC could be used for mouse monoclonal antibody development

SHC owns the comparable immunogenicity to KLH

Generation of SHC-peptide conjugates

SHC purification

Native Shrimp hemocyanin protein( From shrimp, a substitute for KLH)-EpiZyme